BPD Awareness Month (Genetic Predisposition/Disposition) -May 2017-

 

Todays topic is Genetic Predisposition/Disposition (Predisposition relates to body issues). (Disposition relates to Mental illness). Now this may seem like an out of the box type of topic of discussion, but it does have some quality within the BPD diagnosis. It is regarded though in research that Genetic issues MAY relate to Mental illness, its not proven in regards to BPD, but it has some quality research behind it, that can suggest that Genetic disorders could have a hand in your mental illness struggles.

But its to this day still being researched and no direction can be estimated in the mean time. But I thought id share this has a topic of discussion because if it turns out to be true that Genetic issues are reasons for such mental illnesses we suffer then it would be quiet important. This topic requires pure research information, iv not got really any knowledge in this subject, to determine if its possible or not. Ill just share the information and we will see in time if Genetic Predisposition plays a significant part in mental illness.

Now some of this research is based on body issues such has Cancer, obesity, but a lot of research does suggest that body issues and mental issues are 2 sides of the same coin. Which I tend to agree with, if you have a body damaging issue then your mental health will in turn suffer too. So be aware there is a lot of research in this topic today regarding body issues. They use that word diseases I personally detest that word, so that’s why I use the word issues has a replacement for diseases. If you google Genetic Predisposition the 1st 6 suggestions are:

1: Aggression, 2: Breast Cancer, 3: Depression, 4:Anorexia, 5:Addiction,6:Schizophrenia.

CLINICAL INFORMATION

A genetic predisposition (sometimes also called genetic susceptibility) is an increased likelihood of developing a particular disease based on a person’s genetic makeup. A genetic predisposition results from specific genetic variations that are often inherited from a parent. These genetic changes contribute to the development of a disease but do not directly cause it. Some people with a predisposing genetic variation will never get the disease while others will, even within the same family.

Genetic variations can have large or small effects on the likelihood of developing a particular disease. For example, certain mutations in the BRCA1 or BRCA2 genes greatly increase a person’s risk of developing breast cancer and ovarian cancer. Variations in other genes, such as BARD1 and BRIP1, also increase breast cancer risk, but the contribution of these genetic changes to a person’s overall risk appears to be much smaller.

Current research is focused on identifying genetic changes that have a small effect on disease risk but are common in the general population. Although each of these variations only slightly increases a person’s risk, having changes in several different genes may combine to increase disease risk significantly. Changes in many genes, each with a small effect, may underlie susceptibility to many common diseases, including cancer, obesity, diabetes, heart disease, and mental illness.

In people with a genetic predisposition, the risk of disease can depend on multiple factors in addition to an identified genetic change. These include other genetic factors (sometimes called modifiers) as well as lifestyle and environmental factors. Diseases that are caused by a combination of factors are described as multifactorial. Although a person’s genetic makeup cannot be altered, some lifestyle and environmental modifications (such as having more frequent disease screenings and maintaining a healthy weight) may be able to reduce disease risk in people with a genetic predisposition.

Is There A Genetic Predisposition To Mental Illness?

I am in the process of making a decision as to whether or not I will have a family. My mother suffers from clinical depression which was also the case of her two brothers (my uncles). My sister suffers from Manic Depression and I have suffered a nervous breakdown at the age of 23 (now I am 40) with a depression for 2 years. After a lot of effort I managed to get out of it, attended university and now have a successful career. Over the years I have suffered from bouts of depression associated mainly with stress at work and I managed to overcome them without a medication. Seeing my family, including myself suffering all these years, I am hesitant to have a family since I have heard that such diseases can be hereditary.

Answer:

I would like to comment on three major areas.

1.Usually disease is not inherited. Instead, vulnerability to disease is inherited.

2.There are many effective treatments for depression, and intensive research further improves the hope for additional more effective and better tolerated treatments in the future.

3.Details should be discussed with your physician.

Many traits, such as red hair, blue eyes, and some facets of our personality and temperament are inherited, but most disease is not inherited. A few exceptions are diseases associated with a genetic defect such as-hemophilia, Huntington’s, Tay-Sach’s, Gaucher’s, etc. The significance of genes is apparent when we see that identical twins often demonstrate similar personality traits. For example, one set separated since birth had very different developmental backgrounds.

One was raised Jewish in Africa, while the other was raised in the Nazi Youth Movement. Although they never met, they both wore rubber bands on their wrist, and both enjoyed scaring people by sneezing in elevators.

There are many other similar examples demonstrating the significance of genes in determining many facets of personality. In contrast, however, most diseases do not show a 100% correlation in identical twins, or the disease may be present in a very different degree of severity.

There is not a 100% concordance for depression in identical twins. In regard to severity of illness, there was one instance in which all five identical quintuplets all had some signs of schizophrenia, but they all demonstrated a very different degree of the illness. There are about 100,000 genes in the human genome, and about 50,000 affect the central nervous system.

We all have some vulnerabilities, but whether or not these vulnerabilities progress to disease is strongly impacted by many different life events.

There is a statistical correlation between a family history of depression and the risk of developing depression. It is important to point out that your children would have only 50% of your genes.

In addition to genetics, if someone has a history of one prior depression, there is a 50% risk of a second depression. With two depressions, the risk of a third is 70%. With three, the risk is 90%. However, adequate treatment improves the risk factors.

About 17% of the population suffers from depression at some point in their life, and one large study demonstrated that 48% of the population suffers from some form of mental illness at some point in their life. Depression is particularly common in women of child bearing age.

For this reason, the use of antidepressants in pregnancy has been studied, and the information to date is that antidepressants are quite safe-safer that the risks associated with untreated major depression.

There are databases which gather information on this subject. If there is a significant history of depression, PMS, and/or family history of depression, a greater alertness to the possibility of depression and post-partum depression is needed. Effective treatment of post-partum depression in the mother helps reduce the risk of depression and other conditions developing at a later time in the child’s life.

In summary, there is a statistical correlation between a family history of depression, a history of depression, and an increased risk of developing depression in both the patient and their children. This risk, however, should not be overstated and should not be a reason for stigma.

An awareness of the risk, appropriate vigilance, preventive strategies, and early effective treatment if depression does occur improves the prognosis for both you and your children.

A risk of depression, alone should not be a reason not to have children. The details and specific strategies should be discussed confidentially with your personal physician.

id like to thank anyone who took the time to read todays blog on GENETIC PREDISPOSITION/DISPOSITION. feel free to leave any comments or feedback.

Advertisements

Leave a Reply

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out / Change )

Twitter picture

You are commenting using your Twitter account. Log Out / Change )

Facebook photo

You are commenting using your Facebook account. Log Out / Change )

Google+ photo

You are commenting using your Google+ account. Log Out / Change )

Connecting to %s